Duration of challenge immunity to coronavirus JHM in mice
Identifieur interne : 001491 ( Main/Exploration ); précédent : 001490; suivant : 001492Duration of challenge immunity to coronavirus JHM in mice
Auteurs : S. W. Barthold [États-Unis] ; Abigail L. Smith [États-Unis]Source :
- Archives of Virology [ 0304-8608 ] ; 1989-09-01.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (analyse), Attribution aléatoire, Facteurs temps, Foie (anatomopathologie), Foie (microbiologie), Immunité, Intestins (anatomopathologie), Intestins (immunologie), Os nasal (microbiologie), Souris, Souris de lignée BALB C, Tissu lymphoïde (anatomopathologie), Virus de l'hépatite murine (immunologie), Virus de l'hépatite murine (isolement et purification).
- MESH :
- analyse : Anticorps antiviraux.
- anatomopathologie : Foie, Intestins, Tissu lymphoïde.
- immunologie : Intestins, Virus de l'hépatite murine.
- isolement et purification : Virus de l'hépatite murine.
- microbiologie : Foie, Os nasal.
- Pascal (Inist)
- Animaux, Appareil respiratoire pathologie, Attribution aléatoire, Coronavirus murin, Etude comparative, Facteurs temps, Immunisation, Immunité, Modèle animal, Multiplication virus, Réinfection, Réponse immune, Résistance, Sensibilité, Souche, Souris, Souris BALB/c, Souris de lignée BALB C, Tissu lymphoïde associé intestin, Virose, Virus hépatite murine, Voie administration.
English descriptors
- KwdEn :
- Animal model, Animals, Antibodies, Viral (analysis), Comparative study, Immune response, Immunity, Immunization, Intestines (immunology), Intestines (pathology), Liver (microbiology), Liver (pathology), Lymphoid Tissue (pathology), Mice, Mice, Inbred BALB C, Mouse, Murine coronavirus, Murine hepatitis virus, Murine hepatitis virus (immunology), Murine hepatitis virus (isolation & purification), Nasal Bone (microbiology), Random Allocation, Reinfection, Resistance, Respiratory disease, Route of administration, Sensitivity, Strain, Time Factors, Viral disease, Virus multiplication.
- MESH :
- chemical , analysis : Antibodies, Viral.
- immunology : Intestines, Murine hepatitis virus.
- isolation & purification : Murine hepatitis virus.
- microbiology : Liver, Nasal Bone.
- pathology : Intestines, Liver, Lymphoid Tissue.
- Animals, Immunity, Mice, Mice, Inbred BALB C, Random Allocation, Time Factors.
- Teeft :
- Absolute challenge resistance, Antibody titers, Arch virol, Barthold, Brain infection, Challenge immunity, Challenge infection, Challenge resistance, Comparative medicine, Coronavirus, Detectable liver virus, Detectable virus, Experimental mice, Galt, High prevalence, High titers, Immunization, Immunizing infection, Infection, Inoculation, Inoculation results, Intranasal, Intranasal challenge inoculation, Intranasal inoculation, Lesion, Lymphoid tissue, Month interval, Mouse, Mouse hepatitis virus, Nasal, Nasal mucosa, Nasal turbinates, Olfactory mucosa, Rodent coronaviruses, Same coronavirus strain, Sentinel mice, Serum antibody, Sham, Sham inoculation, Shamimmunized mice, Sterile tissue culture fluid, Susceptible mice, Tissue culture fluid, Titer, Treatment groups, Turbinate, Virus strainspecific, Yale university school.
Abstract
Summary: The duration of challenge resistance in mice immunized with mouse hepatitis virus (MHV) strain JHM was examined as a model of immunity to corona-virus infection. Genetically susceptible BALB/cByJ mice were immunized by intranasal (i.n.) or per os (p.o.) inoculation with MHV-JHM or sterile tissue culture fluid (sham) then challenged i.n. with MHV-JHM or sterile tissue culture fluid 1, 6, or 12 months later. Four days after challenge, virus in nasal turbinates and liver was quantified, and prevalance of microscopic lesions in liver and gut-associated lymphoid tissue was tabulated as indices of challenge resistance. MHV-immunized and challenged groups were compared to sham-immunized and challenged groups. Mice immunized by i.n. inoculation were strongly resistant to challenge at 1, 6, and 12 months. Mice immunized by p.o. inoculation were resistant at 1 month, but became partially susceptible to reinfection at 6 and 12 months, based upon all indices. These data indicate that, depending upon route of immunization, mice can become susceptible to reinfection with the same coronavirus strain over time.
Url:
DOI: 10.1007/BF01317914
Affiliations:
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Le document en format XML
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fluid</term><term>Titer</term><term>Treatment groups</term><term>Turbinate</term><term>Virus strainspecific</term><term>Yale university school</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: The duration of challenge resistance in mice immunized with mouse hepatitis virus (MHV) strain JHM was examined as a model of immunity to corona-virus infection. Genetically susceptible BALB/cByJ mice were immunized by intranasal (i.n.) or per os (p.o.) inoculation with MHV-JHM or sterile tissue culture fluid (sham) then challenged i.n. with MHV-JHM or sterile tissue culture fluid 1, 6, or 12 months later. Four days after challenge, virus in nasal turbinates and liver was quantified, and prevalance of microscopic lesions in liver and gut-associated lymphoid tissue was tabulated as indices of challenge resistance. MHV-immunized and challenged groups were compared to sham-immunized and challenged groups. Mice immunized by i.n. inoculation were strongly resistant to challenge at 1, 6, and 12 months. Mice immunized by p.o. inoculation were resistant at 1 month, but became partially susceptible to reinfection at 6 and 12 months, based upon all indices. These data indicate that, depending upon route of immunization, mice can become susceptible to reinfection with the same coronavirus strain over time.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Connecticut</li></region></list><tree><country name="États-Unis"><region name="Connecticut"><name sortKey="Barthold, S W" sort="Barthold, S W" uniqKey="Barthold S" first="S. W." last="Barthold">S. W. Barthold</name></region><name sortKey="Smith, Abigail L" sort="Smith, Abigail L" uniqKey="Smith A" first="Abigail L." last="Smith">Abigail L. Smith</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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